Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1981-10-02
1984-01-17
Daus, Donald G.
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
424246, 424271, 544 16, 544 18, 544 21, 544 22, 544 23, 544 24, 544 25, 544 28, 544 29, C07D50120, A61K 31545
Patent
active
044265204
ABSTRACT:
Penicillin sulfoxide esters are reacted with an isocyanate to produce the corresponding (substituted)-2-carbamoyloxymethylpenam, the corresponding (substituted)-3-carbamoyloxycepham or the corresponding 3-methylcepem. The 6- or 7-side-chain of these products may be cleaved to give the corresponding 6-amino (penams) or 7-amino (cephams and cephems) compounds, and the latter may be reacylated to produce different 6-acyl-2-carbamoyloxymethyl penams, 7-acyl-3-carbamoyloxy cephams and 7-acyl-3-methylcephems. The substituent groups may be removed from the (substituted)-2-carbamoyloxypenams or the (substituted)-3-carbamoyloxycephams to give the corresponding free 2-carbamoyloxymethylpenams or 3-carbamoyloxycephams, respectively.
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Grant, et al. "J. Chem. Soc." (6), 1965, pp. 3842-3845.
Cundall Robert L.
Walker Derek
Bristol-Myers Company
Daus Donald G.
Lloyd Richard R.
Turnipseed James H.
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