3-bicyclicpyridinium-methyl cephalosporins

Details 3-bicyclicpyridinium-methyl cephalosporins 3-bicyclicpyridinium-methyl cephalosporins

1984-12-10

1987-09-08

Rizzo, Nicholas S.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514203, 514204, 514205, 540224, 540225, C07D50138, A61K 31545

Patent

active

046924434

ABSTRACT:
Cephalosporin compounds substituted in the 7-position by a 2-(5- or 6-membered heterocyclic)-2-oximinoacetylamino group and in the 3-position with an imidazolo, oxazolo or thiazolopyridinium-methyl group are broad spectrum antibiotics highly effective in combating bacterial infections of gram-negative and gram-positive microorganisms. The cephalosporins are best prepared by reacting a silylated 7-[2-(heterocyclic)-2-oximinoacetylamino]-3-iodomethyl-3-cephem-4-carboxyl ic acid with an imidazolopyridine, and oxazolopyridine or a thiazolopyridine. Pharmaceutical formulations comprising a compound of the invention and a method for treating bacterial infections comprising their use are also provided.

REFERENCES:
patent: 4278793 (1981-07-01), Durckheimer et al.
patent: 4353824 (1982-10-01), Schindler et al.
patent: 4500526 (1985-02-01), Imae et al.

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