3-bicyclicpyridinium-methyl cephalosporins

Details 3-bicyclicpyridinium-methyl cephalosporins 3-bicyclicpyridinium-methyl cephalosporins

1987-01-12

1988-05-31

Rizzo, Nicholas S.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

540225, 540222, 540227, 514203, 514202, C07D50138, A61K 31545

Patent

active

047481722

ABSTRACT:
Cephalosporin compounds substituted in the 7-position by a 2-(5- or 6-membered heterocyclic)-2-oximinoacetylamino group and in the 3-position with an imidazolo, oxazolo or thiazolopyridinium-methyl group are broad spectrum antibiotics highly effective in combating bacterial infections of gram-negative and gram-positive microorganisms. The cephalosporins are best prepared by reacting a silylated 7-[2-(heterocyclic)-2-oximinoacetylamino-3-iodomethyl-3-cephem-4-carboxyli c acid with an imidazolopyridine, an oxazolopyridine or a thiazolopyridine. Pharmaceutical formulations comprising a compound of the invention and a method for treating bacterial infections comprising their use are also provided.

REFERENCES:
patent: 4500526 (1985-02-01), Smae et al.

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