Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal
Patent
1982-09-21
1984-03-06
Roberts, Elbert L.
Chemistry of carbon compounds
Miscellaneous organic carbon compounds
C-metal
26023957, C07J 100
Patent
active
044353278
ABSTRACT:
A process for the preparation of 3.beta.,7.beta.,15.alpha.-trihydroxy-5-androsten-17-one and the 3,15-dipivalate thereof comprises epimerizing 3.beta.,7.alpha.,15.alpha.-trihydroxy-5-androsten-17-one in the presence of a ketone with or without a solvent, with dilute mineral acid and subsequent treatment with an organic base, and optionally subsequently esterifying the 3.beta.- and 15.alpha.-positions of the resultant 3.beta.,7.beta.,15.alpha.-triol with a reactive derivative of pivalic acid.
REFERENCES:
P. Morand and A van Tongerloo, Steroids 21: 47 (1973).
L. Ruzicka, V. Prelong, and E. Tagmann, Helv. Chim. Acta 27: 1149 (1944).
Chemical Abstracts, vol. 91 (1979) Par. 123928(v).
Laurent Henry
Petzoldt Karl
Wiechert Rudolf
Roberts Elbert L.
Schering Aktiengesellschaft
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