(3-.beta.), 4-.alpha., 16-.beta.)-16, -23, 28-trihdroxyolean-12-

Details (3-.beta.), 4-.alpha., 16-.beta.)-16, -23, 28-trihdroxyolean-12- (3-.beta.), 4-.alpha., 16-.beta.)-16, -23, 28-trihdroxyolean-12-

1997-06-13

1998-12-01

Kunz, Gary L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536 41, A61K 3170, C07H 1524

Patent

active

058439099

ABSTRACT:
The present invention relates to (3.beta., 4.alpha.,16.beta.)-16,23,28-trihydroxyolean-12-ene-3-yl-.beta.-D-glucopyra nuronic acid derivatives and a method for preparing the same from Gymnema inodorum leaves, which comprises treating Gymnema inodorum leaves with an aqueous acid solution, extracting the leaves with an alcohol and/or water, concentrating the extract and subjecting to liquid-liquid partition extraction with water and 1-butanol, concentrating and drying/caking the 1-butanol phase under reduced pressure, defatting the cake, extracting soluble components from the cake with a high polar solvent, concentrating and drying/caking the extract to obtain a purified Gymnema inodorum leaf extract, and then applying the purified extract to HPLC to obtain fractions containing glucose absorption inhibiting substances.

REFERENCES:
Atsuji et al CA 125:257167; JP 08208689A2, Aug. 6, 1996.

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