3.beta.,17.beta.-hydroxy-substituted steroids and related steroi

Details 3.beta.,17.beta.-hydroxy-substituted steroids and related steroi 3.beta.,17.beta.-hydroxy-substituted steroids and related steroi

1988-10-27

1989-11-21

Robinson, Douglas W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Cyclopentanohydrophenanthrene ring system doai

514182, 2603974, 2603975, A61K 3156, C07J 100

Patent

active

048823228

ABSTRACT:
The present invention is directed to a group of compounds which are 3.beta.,17.beta.-hydroxy steriods, and related steroidal structures. These compounds are armatase inhibitors, and thus, regulate or inhibit the conversion of androgens to estrogens. These compounds may be utilized to treat conditions potentiated by the presence of estrogens. These compounds exhibit a slower onset of action and a longer half life relative to the 10-(2-alkynyl) steroidal aromatase inhibitors disclosed in U.S. Pat. No. 4,322,416.

REFERENCES:
patent: 4322416 (1982-03-01), Metcalf et al.
J. O. Johnston, Steroids 50/1-3 (1987).

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