3-benzyl-1,2,4-triazolo[4,3-.alpha.] pyrazines

Details 3-benzyl-1,2,4-triazolo[4,3-.alpha.] pyrazines 3-benzyl-1,2,4-triazolo[4,3-.alpha.] pyrazines

1991-03-22

1992-03-10

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

544350, A61K 31495, C07D48704

Patent

active

050950185

ABSTRACT:
3-benzyl-1,2,4-triazolo [4,3-.alpha.] pyrazines are prepared. They are useful as anticonvulsants.

REFERENCES:
patent: 3629260 (1971-12-01), Maguire et al.
patent: 4056632 (1977-11-01), Mehta et al.
patent: 4438266 (1984-03-01), Hartman
Schneller, et al., J. Heterocyclic Chem., 15, pp. 987-992, Sep. 1978, Formycin Analogs. I. Model Studies in Preparation of an Isomer of Formycin and Related Derivatives (s-Triazolo[4.3-.alpha.]pyrazines).
Kelley, et al., J. Heterocyclic Chem., 25, pp. 1255-1258, Jul.-Aug. 1988, Synthesis and Anticonvulsant Activity of 1-Benzyl-4-Alkylamino-1H-Imidazo[4,5-c]pyridines.
Adachi, et al., J. Org. Chem., vol. 37, No. 2, 1972, pp. 221-225, Studies on Pyrazines. I. The Syntheses of 2,3-Dihydroxyprazines and Their Derivatives.
Woodbury, et al., Arch. int. pharmacodyn., 1952, XCII, No. 1, pp. 97-107, Design and Use of a New Electroshock Seizure Apparatus, and Analysis of Factors Altering Seizure Threshold and Pattern (.sup.1).
Huynh-Dinh, et al., J. Org. Chem., vol. 44, No. 7, 1979, pp. 1028-1035, Synthesis of C-Nucleosides. 17.sup.1 s-Triazolo [4,3-.alpha.]pyrazines.sup.2.

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