3-B-D-ribofuranosylthiazolo [4,5- d ] pyrimidine nucleosides...

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C536S027100, C536S027130, C536S028600, C544S245000, C544S253000, C544S255000, C544S294000, C544S322000, C544S330000, C544S332000, C514S259200

Reexamination Certificate

active

07321033

ABSTRACT:
The invention is directed to 3-β-D-ribofuranosylthiazolo[4,5-d]pyridimine nucleosides and pharmaceutical compositions containing such compounds that have immunomodulatory activity. The invention is also directed to the therapeutic or prophylactic use of such compounds and compositions, and to methods of treating diseases and disorders described herein, by administering effective amounts of such compounds.

REFERENCES:
patent: 4746651 (1988-05-01), Goodman
patent: 4880784 (1989-11-01), Robins et al.
patent: 5041426 (1991-08-01), Robins et al.
patent: 5248672 (1993-09-01), Townsend et al.
patent: 5424295 (1995-06-01), Krenitsky et al.
patent: 5446045 (1995-08-01), Revankar et al.
patent: 5492897 (1996-02-01), Krenitsky et al.
patent: 5539098 (1996-07-01), Krenitsky et al.
patent: 5994321 (1999-11-01), Lewis et al.
patent: 6479463 (2002-11-01), Wang et al.
patent: 6509320 (2003-01-01), Wang et al.
patent: 6566344 (2003-05-01), Gosselin et al.
patent: 6924271 (2005-08-01), Averett et al.
patent: 2002/0058635 (2002-05-01), Averett
patent: 2003/0199461 (2003-10-01), Averett et al.
patent: 2005/0004144 (2005-01-01), Carson et al.
patent: WO-89/05649 (1989-06-01), None
patent: WO 89/05649 (1989-06-01), None
patent: WO-92/16215 (1992-10-01), None
patent: WO-94/17090 (1994-08-01), None
Smee et al., “Immunoenhancing Properties and Antiviral Activity of 7-Deazaguanosine in Mice,” Antimicrobial Agents and Chemotheraphy, Jan. 1991, p. 152-157.
Daskalov et al., “Synthesis and Properties of O6-Substituted Guanosine Derivatives”, Bull. Chem. Soc. Jpn., 54(10:3076-3083 (1981).
Fathi et al., “Synthesis of 6-Substituted 2′-Deoxyguanosine Derivatives Using Trifluoroacetic Anhydride in Pyridine”, Tetrahedron Letters, 31 (3):319-322 (1990).
Goodman, “Role of Salvage and Phosphorylation in the Immunostimulatory Activity of C8-Substituted Guanine Ribonucleosides”, J. Immunol., 14(7):2394-2399 (1988).
Hall et al., “Aldehyde Oxidase from Rabbit Liver: Specificity Toward Purines and Their Analogs”, Archives of Biochemistry and Biophysics, 25(1):36-46 (1986).
International Search Report mailed Mar. 18, 2003 for PCT/US02/38001.
Jones et al., “Di- and Triester Prodrugs of the Varicella-Zoster Antiviral Agent 6-Methoxypurine Arabinoside”, J. Med. Chem., 35(1):56-63 (1992).
Kini et al., “Synthesis and Antiviral Activity of Certain Guanosine Analogues in the Thiazolo[4,5-d]pyrimidine Ring System”, J. Med. Chem., 34(10):3006-30010 (1991).
Krasny et al., “Allopurinol as an Inhibitor of the in vivo Formation of Acyclovir from Desiclovir”, Biochem. Pharm., 35(23):4339-4340 (1986).
Krasny et al., “Metabolism and Pharmacokinetics of a Double Prodrug of a Ganiclovir in the Rat and Monkey ”, Drug Metabolism and Disposition, 23(11):1242-1247 (1995).
Krenistsky et al., “6-Deoxyacyclovir: A xanthjne oxidase-activated prodrug of acyclovir”, Proc. Natl. Acad. Sci., 81:3209-3213 (1984).
Krenitsky et al., “Xanthine Oxidase from Human Liver: Purification and Characterization”, Archives of Biochemistry and Biophysics, 247(1):108-119 (1986).
Nagahara et al., “Thiazolo[4,5-d] pyrimidine Nucleosides. The Synthesis of Certain 3-B-D-Ribofuranosylthiazolo[4,5-d]pyrimidines as Potential Immunotherapeutic Agents”, J. Med. Chem., 33(1):407-415 (1990).
Purifoy et al., “Review of Research Leading to New Anti-Herpesvirus Agents in Clinical Development: Valaciclovir Hydrochloride (256U, the L-Valyl Ester of Acyclovir) and 882C, a Specific Agent for Varicella Zoster Virus”, Journal of Medical Virology Supplement, 1:139-145 (1993).
Reitz et al., “Small-Molecule Immunostimulants. Synthesis and Activity of 7,8-Disubstituted Guanosines and Structurally Related Compounds”, J. Med. Chem., 27(21):3561-3578 (1994).
Revankar et al., “Thiazolo[4,5-d]Pyrimidines. Part II. Synthesis and Anti-human Cytomegalovirus Activity in Vitro of Certain Acyclonucleosides and Acyclonucleotides Derived from Guanine Analogue 5-Aminothiazolo[4,5-d]Pryimidine-2,7(3H,6H)-dione”, Antiviral Chemistry & Chemotherapy, 9:53-63 (1998).
Rida et al., “Synthesis of Novel Thiazolo[4,5-d]Pyrimidine Derivatives for Antimicrobial, Anti-HIV and Anticancer Investigation”, Pharmazie, 51(12):927-931 (1996).
Seela et al., :Alternative d(G-C)3 and d(C-G)3 Hexanucleotides Containing 7-Deaza-2′-deoxyguanosine or 8-Aza-7 deaza-2′-deoxyguanosine in Place of dG, Nucleic Acids Res., 17(3):901-910 (1989).
Smee et al., “Broad-Spectrum Activity of 8-chloro-7-deazaguanosine Against RNA Virus Infections in Mice and Rats”, Antiviral Res., 26:203-209 (1995).
Smee et al., “Broad Spectrum In Vivo Antiviral Activity of 7-Thia-8-Oxoguanoine, A Novel Immunopotentiating Agent”, Antimicrobial Agents and Chemotherapy, 33(9):1487-1492 (1989).
Wong et al., “Photochemical Synthesis of 8-Hydroxyguanine Nucleosides”, Methods Enzymol., 234:59-65 (1994).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

3-B-D-ribofuranosylthiazolo [4,5- d ] pyrimidine nucleosides... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 3-B-D-ribofuranosylthiazolo [4,5- d ] pyrimidine nucleosides..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 3-B-D-ribofuranosylthiazolo [4,5- d ] pyrimidine nucleosides... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-2803188

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.