3'-azido-2',3'-dideoxy-5-halouridine and its use in treating pat

Details 3'-azido-2',3'-dideoxy-5-halouridine and its use in treating pat 3'-azido-2',3'-dideoxy-5-halouridine and its use in treating pat

1986-06-23

1987-12-01

Brown, J. R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536 23, 514934, A61K 3170, C07H 1700

Patent

active

047104929

ABSTRACT:
This invention relates to 3'-azido-2',3'-dideoxy-5-halouridine, particularly, 3'-azido-2', 3'-dideoxy-5-bromouridine and 3'-azido-2',3'-dideoxy-5-iodouridine, and its use in treating patients infected with a retrovirus.

REFERENCES:
patent: 4604382 (1986-08-01), Lin et al.
Journal of Medicinal Chemistry, 21, 109, (1978), "Synthesis and Biological Activity of Several Amino Analogues of Thymidine", by Tai-Shun Lin and William H. Prusoff.
Journal of Medicinal Chemistry, 21, 106, (1978), "A Novel Synthesis and Biological Activity of Several 5-Halo-5'-Amino Analogues of Deoxyribopyrimidine Nucleosides", by Tai-Shun Lin and William H. Prusoff.
Journal of Medicinal Chemistry, 26, 1691 (1983), "Synthesis and Biological Activity of Various 3'-Azido and 3'-Amino Analogues of 5-Substituted Pyrimidine Deoxyribonucleosides", by Tai-Shin Lin, You-Song Gao & William R. Mancini.
Proc. Natl. Acad. Sci. USA, 82, 7096, (1985), "3'-Azido-3'-3'-Deoxythymidine (BW A509U): An Antiviral Agent that Inhibits the Infectivity and Cytopathic Effect of Human T-Lymphotropic Virus Type III/Lymphadenopathy-Associated Virus In Vitro", by Hiroaki Mitsuya, Kent J. Weinhold, Phillip A. Furman, Marty H. St. Clair, Sandra Nusinoff Lehrman, Robert C. Gallo, Dani Bolognesi, David W. Barry and Samuel Broder.

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