3-arylthioindole-2-carboxamide derivatives and analogs...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C514S414000, C548S469000

Reexamination Certificate

active

08008340

ABSTRACT:
A method for inhibiting casein kinase Iε activity, comprising administering to said patient a therapeutically effective amount of a compound of formula I.its stereoisomer, enantiomer, racemate, tautomer or pharmaceutically acceptable salt thereof.

REFERENCES:
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patent: WO 2004/014300 (2004-02-01), None
patent: WO 2005/061498 (2005-07-01), None
Boschelli et al. “Inhibition of E-Selectin-,ICAM-1, and VCAM-1-Mediated Cell Adhesion by Benzo[b]thiphene, Benzofuran-, Indole-, and Naphthalene-2-carboxamides: Identification of PD 144795 as an Antiinflammatory Agent” J. Med. Chem., 1995, vol. 38, pp. 4597-4614.
Hasegawa, M., et. al.,, Regulation of the Circadian Oscillator inXenopusRetinal Photoreceptors by Protein Kinases Sensitive to the Stress-Activatived Protein Kinase Inhibitor, SB203580, The Journal of Biological Chemistry, vol. 279, No. 21 pp. 22738-22746 (2004).

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