Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2003-10-24
2008-08-26
Solola, Taofiq A (Department: 1625)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C549S051000
Reexamination Certificate
active
07417064
ABSTRACT:
There is provided a compound of formula (I) wherein A is selected from —O— and —S—; X is selected from C2-C8alkyl, C2-C8alkenyl, C3-C8cycloalkyl and C4-C8cycloalkylalkyl, each of which may be optionally substituted with up to 3 substituents each independently selected from halo, C1-C4alkyl, C1-C4alkoxy, C1-C4alkyl-S(O)n— where n is 0, 1 or 2, —CF3, —CN and —CONH2; Y is selected from phenyl, naphthyl, dihydrobenzothienyl, benzothiazolyl, benzoisothiazolyl, quinolyl, isoquinolyl, naphthyridyl, thienopyridyl, indanyl, 1,3-benzodioxolyl, benzothienyl, indolyl and benzofuranyl, each of which may be optionally substituted with up to 4 or, where possible, 5 substituents each independently selected from halo, C1-C4alkyl, C1-C4alkoxy, C1-C4alkyl-S(O)n— where n is 0, 1 or 2, nitro, acetyl, —CF3, —SCF3and cyano; and when Y is indolyl it may be substituted or further substituted by an N-substituent selected from C1-C4alkyl; Z is selected from H, OR3or F, wherein R3is selected from H, C1-C6alkyl and phenyl C1-C6alkyl; R1and R2are each independently H or C1-C4alkyl; with the proviso that, when Z is H, then Y may not be optionally substituted phenyl or optionally substituted naphthyl.
REFERENCES:
patent: 4018895 (1977-04-01), Molloy et al.
patent: 4229449 (1980-10-01), Melloni et al.
patent: 4956388 (1990-09-01), Robertson et al.
patent: 5023269 (1991-06-01), Robertson et al.
patent: 5776969 (1998-07-01), James
patent: 0373836 (1990-06-01), None
patent: 0814084 (1997-12-01), None
patent: 2 060 622 (1981-05-01), None
patent: WO-96/09288 (1996-03-01), None
patent: WO 00/02551 (2000-01-01), None
patent: WO 01/62714 (2001-08-01), None
patent: WO-02/094262 (2002-11-01), None
patent: WO 03/011831 (2003-02-01), None
patent: WO 2004/043931 (2004-05-01), None
King, Med Chem: Principle and Practice (1994), p. 206-208.
Lemke T.L. et al., β-Adrenergic Blocking Agents, α- and γ-Methly(aryloxy)propanolamines, J. Med. Chem. 1981, 24, 1211-1214, XP-002275394.
Database Beilstein, Beilstein Institute for Organic Chemistry, Frankfurt-Main, DE, XP002275395, Nov. 30, 1988, Abstract.
Boulet Serge Louis
Filla Sandra Ann
Gallagher Peter Thaddeus
Hudziak Kevin John
Johansson Anette Margareta
Eli Lilly and Company
Solola Taofiq A
Titus Robert D.
Winter Mark A.
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