Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2003-10-24
2008-08-12
Solola, Taofiq A (Department: 1625)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C549S051000
Reexamination Certificate
active
07410996
ABSTRACT:
There is provided a compound of formula (I) wherein A is selected from —O— and —S—; X is selected from phenyl optionally substituted with up to 5 substituents each independently selected from halo, C1-C4alkyl and C1-C4alkoxy, thienyl optionally substituted with up to 3 substituents each independently selected from halo and C1-C4alkyl, and C2-C8alkyl, C2-C8alkenyl, C3-C8cycloalkyl and C4-C8cycloalkylalkyl, each of which may be optionally substituted with up to 3 substituents each independently selected from halo, C1-C4alkyl, C1-C4alkoxy, C1-C4alkyl-S(O)n— where n is 0, 1 or 2, —CF3, —CN and —CONH2; Y is selected from phenyl, naphthyl, dihydrobenzothienyl, benzothiazolyl, benzoisothiazolyl, quinolyl, isoquinolyl, naphthyridyl, thienopyridyl, indanyl, 1,3-benzodioxolyl, benzothienyl, indolyl and benzofuranyl, each of which may be optionally substituted with up to 4 or, where possible, up to 5 substituents each independently selected from halo, C1-C4alkyl, C1-C4alkoxy, C1-C4alkyl-S(O)n— where n is 0, 1 or 2, nitro, acetyl, —CF3, —SCF3and cyano; and when Y is indolyl it may be substituted or further substituted by an N-substituent selected from C1-C4alkyl; Z is selected from OR3or F, wherein R3is selected from H, C1-C6alkyl and phenyl C1-C6alkyl; R1and R2are each independently H or C1-C4alkyl; and pharmaceutically acceptable salts thereof with the proviso that when Y is optionally substituted phenyl or optionally substituted 1,3-benzodioxolyl and Z is OR3and X is optionally substituted phenyl then A is —S—.
REFERENCES:
patent: 4018895 (1977-04-01), Schmiegel et al.
patent: 5023269 (1991-06-01), Robertson et al.
patent: 5776969 (1998-07-01), James
patent: 0373836 (1990-06-01), None
patent: 2 060 622 (1981-05-01), None
patent: WO 96/09288 (1996-03-01), None
patent: WO 97/45115 (1996-03-01), None
patent: WO 00/02551 (2000-01-01), None
patent: WO 01/62714 (2001-08-01), None
patent: WO 02/094262 (2002-11-01), None
patent: WO 2004/043931 (2004-05-01), None
patent: WO 2004/043904 (2007-05-01), None
King, Med Chem: Principle and Practice (1994), p. 206-209.
Meloni P. et al., XP000605241, “Potential Antidepressant Agents-Alpha-Aryloxy-Benzyl Derivatives of Ethanolamine and Morpholine” European Journal of Medicinal Chemistry, editions Scientifique Elsevier, Paris, Fr, vol. 19, No. 3, 1984, pp. 235-242.
Boulet Serge Louis
Filla Sandra Ann
Gallagher Peter Thaddeus
Hudziak Kevin John
Johansson Anette Margareta
Anderson Arvie J.
Eli Lilly and Company
Solola Taofiq A
Titus Robert D.
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