3-aryloxy and 3-arylthioazetidinecarboxamides as anticonvulsants

Details 3-aryloxy and 3-arylthioazetidinecarboxamides as anticonvulsants 3-aryloxy and 3-arylthioazetidinecarboxamides as anticonvulsants

1986-10-22

1990-09-11

Shah, Mukund J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

540515, 540596, 544111, 544349, 544359, 546208, 546256, 546275, 548336, 548524, 548952, A61K 31395

Patent

active

049563599

ABSTRACT:
Novel 3-aryloxy and 3-arylthioazetidinecarboxamides having utility in a method of treating convulsions and epilepsy and compositions therefor are disclosed having the formula: ##STR1## wherein Z is oxygen or sulfur; B is oxygen or sulfur; Ar is pyridyl or halo-substituted-pyridyl, phenyl or substituted phenyl; R.sup.1 and R.sup.2 are selected from hydrogen, loweralkyl, aryl, allyl, substituted allyl, propargyl, cycloalkyl, loweralkylcycloalkyl, cycloalkylloweralkyl, arylloweralkyl, diloweralkylaminoloweralkyl, and R.sup.1 and R.sup.2 when taken with the adjacent nitrogen atom may form a heterocyclic radical; R.sup.3 is hydrogen, loweralkyl, aryl or arylloweralkyl, and the geometrical isomers thereof, excepting that when R.sup.3 is hydrogen, Z is oxygen, B is oxygen, and Ar is phenyl or phenyl substituted by trifluoromethyl or aminocarbonyl, then R.sup.1 and R.sup.2 cannot be a combination of hydrogen and loweralkyl, and the further exception that when R.sup.3 is hydrogen, Z is oxygen, B is oxygen, and Ar is phenyl or phenyl substituted by fluoro, loweralkyl, loweralkoxy, trifluoromethyl, acetyl, or aminocarbonyl, then R.sup.1 and R.sup.2 cannot both be hydrogen.

REFERENCES:
patent: 4226861 (1980-10-01), Cale, Jr.
patent: 4505907 (1985-03-01), Wright et al.
patent: 4571393 (1986-02-01), Teng
patent: 4594189 (1986-01-01), Lo et al.
Albertson, et al., Chem. Abstracts vol. 101 (1984), entry 183856e.
Osman, et al., Chem. Abstracts vol. 102 (1985), entry 72276S.

Affiliated with

Also associated with

Rating

3-aryloxy and 3-arylthioazetidinecarboxamides as anticonvulsants does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 3-aryloxy and 3-arylthioazetidinecarboxamides as anticonvulsants, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 3-aryloxy and 3-arylthioazetidinecarboxamides as anticonvulsants will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1184954