3-Aryloxy-3-aryl-propaneamines and their method of use

Details 3-Aryloxy-3-aryl-propaneamines and their method of use 3-Aryloxy-3-aryl-propaneamines and their method of use

1979-02-22

1981-10-20

Hines, Robert V.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Recombinant or stably-transformed bacterium encoding one or...

26050118, 26050119, 424330, 564220, 564346, 564347, 564355, A01N 3730, A61K 31135, C07C 9302

Patent

active

042961262

ABSTRACT:
Novel benzene-propanamines of the formula ##STR1## wherein X is selected from the group consisting of hydrogen, chlorine, fluorine and bromine, R.sub.1 is selected from the group consisting of hydrogen and alkyl of 1 to 5 carbon atoms, R.sub.2 is alkyl of 1 to 5 carbon atoms, R.sub.3 is selected from the group consisting of hydrogen, chlorine, bromine, --CF.sub.3, methyl and methoxy when R.sub.4 is nitro and R.sub.3 is selected from the group consisting of amino and acetamido when R.sub.4 is hydrogen and their non-toxic, pharmaceutically acceptable acid addition salts having anorexigenic activity and inhibit serotonine uptake in vivo and in vitro and their preparation.

REFERENCES:
patent: 2683742 (1954-07-01), Cusic
patent: 3106564 (1963-10-01), Fleming et al.
patent: 3496195 (1970-02-01), Ecsery et al.
patent: 4018895 (1977-04-01), Molloy et al.

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