Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...
Patent
1977-05-23
1978-08-01
Coughlan, Jr., Paul M.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Bacterium or component thereof or substance produced by said...
26029357, 2602948C, 260301, 424263, 424267, 544368, A61K 31495, C07D41712
Patent
active
041043871
ABSTRACT:
3-(Arylcycloiminoalkyl)benzisothiazole 1,1-dioxides are provided having the structure ##STR1## wherein R is hydrogen, halogen, lower alkyl, lower alkoxy or nitro; R.sup.1 is hydrogen, lower alkoxy or halogen with the proviso that R.sup.1 can be lower alkoxy or halogen only when R is lower alkoxy or halogen, respectively; A is O or NH; X is hydrogen, halogen lower alkyl, lower alkoxy, or trifluoromethyl; Y is C or N, where Y is C, is a double bond, and when Y is N, represents a single bond, B is an alkylene group containing 2 to 5 carbons in the normal chain; Q is a single bond or an alkylene group containing 1 to 3 carbons in the normal chain; and physiologically acceptable acid-addition salts thereof. These compounds are useful as antiinflammatory agents.
REFERENCES:
patent: 2751392 (1956-06-01), Grogan et al.
patent: 3787411 (1974-01-01), Ruschig et al.
patent: 4000274 (1976-12-01), Renth et al.
Kissick Thomas P.
Wade Peter C.
Coughlan, Jr. Paul M.
E. R. Squibb & Sons Inc.
Levinson Lawrence S.
Rodney Burton
Smith Merle J.
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