3-aryl or 3-hetaryl-.beta.-carbolines, their production and use

Details 3-aryl or 3-hetaryl-.beta.-carbolines, their production and use 3-aryl or 3-hetaryl-.beta.-carbolines, their production and use

1994-10-25

1996-08-06

Rotman, Alan L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

544333, 546 86, 546 87, C07D47104, C07D40112, C07D40512, C07D40912

Patent

active

055435190

ABSTRACT:
Compounds of formula I are described ##STR1## in which R.sup.3 represents a C.sub.6-12 -aryl or hetaryl radical, optionally substituted singly or multiply with C.sub.1-4 -alkyl, C.sub.3-7 -cycloalkyl, halogen, C.sub.1-4 -alkoxy-C.sub.1-2 -alkyl, phenyl or amino, the process for their production and their use in pharmaceutical agents.

REFERENCES:
patent: 4435403 (1984-03-01), Braestrup et al.
patent: 4596808 (1986-06-01), Braestrup et al.
patent: 4645773 (1987-02-01), Engelstoft et al.
patent: 4705856 (1987-11-01), Biere
patent: 4877792 (1989-10-01), Biere et al.
patent: 4894377 (1990-01-01), Seidelmann et al.
patent: 4933345 (1990-06-01), Huth et al.
patent: 4945090 (1990-07-01), Schmiechen et al.
Liebigs Annalen Der Chemie, vol. 86, No. 10 (Oct. 1986), Weinheim DE, pp. 1749-1764; H. Biere et al.: "Eine neue und besonders einfache Synthese von Zentralaktiven beta-Carbolin-derivaten", see p. 1749, paragraph 1, see p. 1762; Example 6K.

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