3-Aryl-3-aryloxypropylamines

Details 3-Aryl-3-aryloxypropylamines 3-Aryl-3-aryloxypropylamines

1980-09-03

1982-05-18

Ford, John M.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

546300, A61K 3144, C07D21363, C07D21364

Patent

active

043305466

ABSTRACT:
3-Aryl-3-aryloxyalkylamines of the general formula (I) ##STR1## and their pharmaceutically acceptable acid addition salts, wherein R.sup.1, R.sup.2, R.sup.4 and R.sup.5 are hydrogen or lower alkyl, R.sup.3 is hydrogen, lower alkyl or benzyl, Ar is phenyl optionally substituted by one or more halogen, trifluoromethyl, lower alkyl, lower alkoxy, nitro or amino groups, and Ar.sup.1 is methylsulphinyl, methylsulphonyl- or cyano-substituted phenyl, 2- or 4-pyridyl, 2-pyrazinyl, 2-quinolinyl, 2-thienyl or 2-thiazolyl exhibit activity on the central nervous system, e.g. as antidepressants.

REFERENCES:
patent: 2683742 (1954-07-01), Cusic
patent: 3106564 (1963-10-01), Fleming et al.
patent: 4060601 (1977-11-01), Baldwin
patent: 4194009 (1980-03-01), Molloy et al.
patent: 4195090 (1980-03-01), Frei et al.

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