Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1997-12-18
1999-10-26
Morris, Patricia L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
546198, A61K 31445, C07D41704
Patent
active
059729635
ABSTRACT:
This invention relates to 3-aryl-2-(1-substituted-4-piperidinyl)-1,1-dioxo-3H-benzo[d]isothiazoles and related compounds of the formula, ##STR1## where X and Y are independently halogen, loweralkyl, loweralkoxy, arylloweralkoxy, acyl, hydroxy, nitro, amino, trifluoromethyl and hydrogen; n, p and q are independently integers of 1 or 2; R is hydrogen, loweralkyl, aryloweralkyl, acyl, --(CH.sub.2).sub.m --OR.sub.1,--(CH.sub.2)NHR.sub.1, ##STR2## where R.sub.1 is hydrogen, loweralkyl, arylloweralkyl, acyl and loweralkoxycarbonyl; Z is hydrogen, halogen, loweralkyl, loweralkoxy and acyl; m is an integer of 2 to 4; is an integer of 1 or 2; and the pharmaceutically acceptable acid addition salts thereof and the optical isomers thereof where such isomers exist.
REFERENCES:
J. Szabo et al., Tetrahedron vol. 45, No. 9, pp. 2731-2736 (1989).
P. Feit, et al., J. of Med. Chem., vol. 16, No. 2, pp. 127-130 (1973).
H. Watanabe, et al., J. Org. Chem., vol. 33, No. 2, pp. 900-903 (1968).
Merriman Gregory H.
Rauckman Barbara S.
Hoechst Marion Roussel Inc.
Morris Patricia L.
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