3-Aralkyloxy-2,3-dihydro-2-(imidazolylmethyl)benzo(b)thiophenes

Details 3-Aralkyloxy-2,3-dihydro-2-(imidazolylmethyl)benzo(b)thiophenes 3-Aralkyloxy-2,3-dihydro-2-(imidazolylmethyl)benzo(b)thiophenes

1980-12-12

1982-10-05

Jiles, Henry R.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

548336, 548203, 544376, 546274, 546176, 424273R, 424263, 424270, A01N 4342, A01N 4350, C07D40508, C07D21512

Patent

active

043528082

ABSTRACT:
3-Aralkyloxy-2,3-dihydro-2-(imidazolylmethyl(benzo(b)thiophenes and related derivatives having antifungal, antibacterial, and antiprotozoal activity are prepared by the reaction of the corresponding 2,3-dihydro-3-hydroxy-2-(imidazolylmethyl)benzo(b)thiophene or related derivative and an aralkyl halide.
Preferred compounds are those where the aralkyl function is a hetercyclic aromatic, particularly 2-chloro-3-thenyl, and where the benzene nucleus is substituted by chlorine or fluorine.
Pharmaceutical formulations comprising compounds of this invention are described, as well as the method for their use in treating microbial infections.

REFERENCES:
patent: 3927018 (1975-12-01), Houlihan
patent: 4036970 (1977-07-01), Walker et al.
patent: 4078071 (1978-03-01), Walker et al.
patent: 4267179 (1981-05-01), Heeres et al.
patent: 4269845 (1981-05-01), Worthington et al.

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