Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1997-09-30
1999-02-16
Shah, Mukund J.
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
540222, 540224, C07D50118, C07D50124
Patent
active
058722491
ABSTRACT:
A 3-ammoniopropenyl cephalosporin of the following formula (I): ##STR1## wherein P is hydroxylated alicyclic or aliphatic amines such as meso-3,4-dihydroxy-1-methylpyrrolidine, (3S,4S)-3,4-dihydroxy-1-methylpyrrolidine, (3R,4R)-3,4-dihydroxy-1-methylpyrrolidine, rac-3,4-trans-dihydroxy-1-methylpyrrlidine, (2S,4R)-4-hydroxy-1-methyl-2-pyrrolidinemethanol, N-methyl-bis(2-hydroxyethyl)amine, 3,4-cis-dihydroxy-1-methylpiperidine, 3,4-trans-dihydroxypiperidine, 4-hydroxy-1-methylpiperidine, 2-hydroxymethyl-1-methylpiperidine, or tropine, or a pharmaceutically acceptable salt thereof, exhibits good anti-bacterial activities against a wide variety of Gram-positive and Gram-negative bacteria; and a process for the preparation thereof.
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Kamachi et al., "Synthesis of a New Series of Cephalosporins Having 3-Substituted-Ammonio-1-Propenyl Group as the C-3 Side Chain", J. of Antibiotics, 5:533-543 (May, 1990).
Lee Jae Yeol
Lee Yong Sup
Park Hokoon
Suk Dae Hwan
Woo Eun-Rhan
Korea Institute of Science and Technology
Shah Mukund J.
Sripada Pavanaram K.
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