3-Aminosydnonimines, their preparation and use

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...

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544 582, 544 587, 544 60, 544367, 424250, C07D27104, C07D27910, A61K 3138, A61K 3141

Patent

active

043059392

ABSTRACT:
Physiologically-acceptable 3-aminosydnonimines of the formula ##STR1## and their pharmacologically-acceptable acid-addition salts, when formulated into medicament dosage forms, are useful for reducing systemic blood pressure, pulmonary artery pressure and left ventricular end diastolic pressure when orally administered to patients in need of such pressure reduction. These compounds are prepared by cyclizing a compound which, in its free-base state, is of the formula ##STR2## to a corresponding product which, in its free-base state, is of the formula ##STR3## and, when R.sup.2 is other than --H, acylating that product.

REFERENCES:
patent: 3833580 (1974-09-01), Gotz
patent: 3898230 (1975-08-01), Regnier

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