3-Aminosydnonimines, their preparation and use

Details 3-Aminosydnonimines, their preparation and use 3-Aminosydnonimines, their preparation and use

1981-02-10

1982-06-01

Ford, John M.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

544 60, 544 587, C07D41704, A61K 3138, A61K 3141, C07D41714

Patent

active

043328016

ABSTRACT:
Physiologically-acceptable 3-aminosyndnonimines of the formula ##STR1## and their pharmacologically-acceptable acid-addition salts, when formulated into medicament dosage forms, are useful for reducing systemic blood pressure, pulmonary artery pressure and left ventricular end diastolic pressure when orally administered to patients in need of such pressure reduction. These compounds are prepared by cyclizing a compound which, in its free-base state, is of the formula ##STR2## to a corresponding product which, in its free-base state, is of the formula ##STR3## and, when R.sup.2 is other than --H, acylating that product.

REFERENCES:
patent: 3833580 (1974-09-01), Gotz
patent: 3898230 (1975-08-01), Regnier

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