Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...
Patent
1981-02-10
1984-06-05
Daus, Donald G.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Bacterium or component thereof or substance produced by said...
544367, 544366, 544 60, 544 582, 424246, 4242484, 424251, C07D40304, C07D41304, A61K 3138, A61K 3141
Patent
active
044527977
ABSTRACT:
Physiologically-acceptable 3-aminosydnonimines of the formula ##STR1## and their pharmacologically-acceptable acid-addition salts, when formulated into medicament dosage forms, are useful for reducing systemic blood pressure, pulmonary artery pressure and left ventricular end diastolic pressure when orally administered to patients in need of such pressure reduction. These compounds are prepared by cyclizing a compound which, in its free-base state, is of the formula ##STR2## to a corresponding product which, in its free-base state, is of the formula ##STR3## and, when R.sup.2 is other than -H, acylating that product.
REFERENCES:
patent: 3642793 (1972-02-01), Imashiro et al.
patent: 3812128 (1974-05-01), Masuda et al.
patent: 3833580 (1974-09-01), Gotz et al.
patent: 3833583 (1974-09-01), Simpson
patent: 4147870 (1979-04-01), Garcia et al.
Beyerle Rudi
Fiedler Volker
Martorana Piero A.
Nitz Rolf-Eberhard
Schonafinger Karl
Cassella Aktiengesellschaft
Daus Donald G.
Gibson S. A.
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