Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1990-11-16
1996-03-26
Brust, Joseph Paul
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514326, 514412, 514422, 514423, 544141, 546208, 548516, 548518, 548532, A61K 3140, A61K 31445, A61K 31535
Patent
active
055020518
ABSTRACT:
The invention is directed to 3-aminopyrroles of formula I, which are largely new, to methods for the preparation and to their use as medicinal agents and preparations, as well as to anti-convulsive or analgesic preparations containing these 3-aminopyrroles.
Disubstituted and monosubstituted amino groups are claimed as 3-amino substituents.
The invention pursues the objective of developing largely new 3-aminopyrroles, which have CNS activity, particularly ones which anti-convulsive or analgesic properties, as well as methods for their preparation and their use as medicinal preparations.
Pursuant to the invention, the synthesis is carried out by cyclizing open-chain precursors, such as aminoacrylic acid derivative, or by modifying pyrroles.
REFERENCES:
patent: 4198502 (1980-04-01), Tarzia et al.
Knoll, et al.; Chimija Geterociklicheskih Soedinenijg (1985), No. 5, pp. 628-630 (Synthesis ester of substituted .beta.-aminopyrrole-2-carboxylis acids from thioacrylic acids and alycine ethers.
Tarzia, et al.; Farmaco, Ed. Sci. (1984), 39(6), pp. 538-558; Synthesis and pharmacological evalution of a series of analgesic and antiinflammatory 4-aminopyrroles.
Faust Gottfried
Knoll Alexander
Liebscher Ju/ rgen
Lohman Dieter
Morgenstern Eveline
Arzneimittelwerk Dresden GmbH
Brust Joseph Paul
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