Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1987-01-14
1990-12-11
Higel, Floyd D.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
5142378, 514259, 514260, 514261, 514383, 514393, 514395, 514398, 514403, 514404, 514405, 514415, 514416, 514418, 514419, 514427, 514438, 514447, 514448, 514459, 514471, 514472, 544134, 544319, 544336, 546153, 546323, 548371, 564 47, 564 56, 564182, 564186, C09D 3310, C07C10344, C07C12175, C07C12719, C07C20732, C07C12180, A61K 3138, A61K 3116, A61K 3117
Patent
active
049771531
ABSTRACT:
Compounds of formula (I), ##STR1## characterized in that R signifies optionally substituted heteroaryl-, heteroarylakyl or heteroarylalkenyl, R.sub.1 signifies hydrogen or a substituent, R.sub.2 is hydroxy or a group --z--(CH.sub.2).sub.n --Y--R.sub.3 wherein R.sub.3 is hydrogen, alkyl, hydroxyalkyl, alkenyl, cycloalkyl, cycloalkylalkylene, hydroxy substituted cycloalkyl or cycloalkylalkylene, or optionally substituted aryl or aralkyl or aralkenyl moiety, and Y signifies oxygen or sulfur, and either Z is an oxygen atom and n is 2 or 3, or Z is a bond and n is 1, 2 or 3, A signifies alkylene or branched alkylene of 2 to 5 carbon atoms, W signifies a bond or imino, and X signifies a bond or imino, and their physiologically hydrolyzable derivatives, in which at least one hydroxy group is in esterified form. The compounds exhibit beta adrenoceptor blocking activity. Processes for the preparation of the compounds are also disclosed.
REFERENCES:
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patent: 4035420 (1977-07-01), Berntsson et al.
patent: 4083992 (1978-04-01), Smith
patent: 4141987 (1979-02-01), Smith
patent: 4327113 (1982-04-01), Smith
Berthold Richard
Louis William J.
Seiler Max-Peter
Stoll Andre
Higel Floyd D.
Louis William J.
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