3-(Aminopropyl)indoles

Details 3-(Aminopropyl)indoles 3-(Aminopropyl)indoles

1973-02-16

1976-04-27

Narcavage, Joseph A.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

26029361, 26037615, 260296B, 424248, 424263, 424267, 424274, C07D20914

Patent

active

039534421

ABSTRACT:
Pharmacologically valuable 3-(aminopropyl)-indoles have the general formula ##SPC1##
In which R.sub.1 is phenyl, halophenyl, nitrophenyl, aminophenyl, loweralkoxyphenyl or pyridyl, R.sub.2 is hydrogen or methyl, R.sub.3 and R.sub.4 are each hydrogen or lower alkyl or taken together form a polymethylene group which may be interrupted by oxygen so that --NR.sub.3 R.sub.4 is a heteromonocycle having 5 or 6 nuclear atoms and R.sub.5 is hydrogen, fluorine, chlorine or methoxy. Especially interesting are those compounds in which at least one of R.sub.1 and R.sub.5 comprises a flourine atom and --NR.sub.3 R.sub.4 is pyrrolidino. The compounds are made by condensation of correspondingly substituted indolylacetones with amines HNR.sub.3 R.sub.4 in a reducing medium or, in certain cases, by reduction of correspondingly substituted indolylacetoximes with or without subsequent lower alkylation.

REFERENCES:
grandberg Dal, Chem. Abs. 74:53400g (1971).
Canas-Rodriguez et al. Chem Abs. 75:5690h (1971) abs. of Brit. Pat. 1220628.

Affiliated with

Also associated with

Rating

3-(Aminopropyl)indoles does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 3-(Aminopropyl)indoles, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 3-(Aminopropyl)indoles will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2001919