3-(aminomethyliden) 2-indolinone derivates and their use as...

Details 3-(aminomethyliden) 2-indolinone derivates and their use as... 3-(aminomethyliden) 2-indolinone derivates and their use as...

2011-07-19

2011-07-19

Saeed, Kamal (Department: 1622)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C514S235200, C514S323000, C514S418000, C540S544000, C544S144000, C546S201000, C548S486000

Reexamination Certificate

active

07981880

ABSTRACT:
The present invention encompasses compounds of general formula (1) wherein R1, R2, R3and X are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and the use thereof for preparing a pharmaceutical composition having the above-mentioned properties.

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Joel R. Huff, HIV Protease: A Novel Chemotherapeutic Target for AIDS, 1991, Journal of Medicinal Chemistry, vol. 34, No. 8, pp. 2305-2314.
Lala et al., Role of nitric oxide in tumor progression: Lessons from experimental tumors, 1998, Cancer and Metastasis Reviews, 17(1), 91-106.
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International Search Report for PCT/EP2007/053959 mailed Aug. 27, 2007.

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