3-aminoalkyl-1H-indole-5-urea and amide derivatives

Details 3-aminoalkyl-1H-indole-5-urea and amide derivatives 3-aminoalkyl-1H-indole-5-urea and amide derivatives

1982-09-29

1989-02-07

Berch, Mark L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548504, 548507, 548467, 548468, 546273, 514415, C07D20916, C07D40114, C07D40112, A61K 3140

Patent

active

048032182

ABSTRACT:
Compounds useful as antihypertensive agents which are 3-aminoalkyl-1H-indole-5-urea or amide derivatives having the following formula: ##STR1## or a pharmaceutically acceptable acid addition salts thereof, wherein: R is C.sub.1-4 loweralkyl, C.sub.1-4 loweralkoxy, phenyl, ##STR2## pyrrolyl, pyridyl or is a substituted nitrogen represented by: ##STR3## wherein R.sub.1 is H or a C.sub.1-4 loweralkyl or phenyl or cycloalkyl; R.sub.2 is H or a C.sub.1-4 loweralkyl; Y is H or halo; R.sub.3 is H or a C.sub.1-4 loweralkyl; R.sub.4 is H or a C.sub.1-4 loweralkyl; R.sub.5 is H or a C.sub.1-4 loweralkyl or carboxymethyl or carboxytrifluoromethyl; R.sub.6 is H or a C.sub.1-4 loweralkyl, and R.sub.5 and R.sub.6 may also be taken together as an N-loweralkyl-pyrrolidinylidene group.

REFERENCES:
patent: 2890223 (1959-06-01), Woolley et al.
patent: 2995566 (1961-08-01), Sletzinger et al.
patent: 2995567 (1961-08-01), Sarett et al.
patent: 3182071 (1965-05-01), Shavel et al.
patent: 3472870 (1969-10-01), Larsen et al.
patent: 3489429 (1970-01-01), Herbst
patent: 4064255 (1977-12-01), Champsein et al.
patent: 4252803 (1981-02-01), Webb
Boltze, et al., "Substituted Indole-3-Acetoxy-Alkylsulfonic Acid Salts," Chem. Abst. 91:5110z (1979).
Glennon and Gessner, "Serotonin Receptor Binding . . . ," Chem Abst. 90:132591 (1979).
Coates, et al., "Indole Derivatives . . . ," Chem. Abst. 97:6148d (1982).
McOnie, Protective Groups in Organic Chem. Plenum Press, New York, (1973) pp. 48, 49, 76, 77, 80, and 81.
Goodman, et al., Pharmacological Basis of Therapeutics, Macmillan, New York (1965) pp. 651-653.

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