Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1984-10-09
1987-03-31
Ford, John M.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
540467, 540481, 540470, 540544, 540553, 540575, 540597, 544 54, 514852, 424 59, 424 64, 424 47, A61K 3154, A61K 706, C07D27904, C07D41704
Patent
active
046543392
DESCRIPTION:
BRIEF SUMMARY
The invention relates to 3-amino-tetrahydro-1,3-thiazin-2,4-diones as well as skin treating compositions containing said compounds.
The skin forms the limiting layer between the organism and its environment. Therefore, the most important task of the skin consists of protecting the inside of the body against exogenic influences. Our skin is in daily contact with substances wich are strange to the body and partially hostile to the body and in particular hostile to the skin. Particularly frequent contact of the unprotected skin with these substances, which very often are job related (hairdressers, dentists, housewives), sooner or later results in more or less damage to the skin. For preventing or at least for reducing such skin damage principally two types of intervention was hitherto used: a protective skin protection as well as a conserving skin care.
The protective skin protection consists in that the skin is treated before coming into contact with the strange i.e., foreign skin substance, so as to substantially exclude any direct contact between the skin surface and the damaging substances. The preparations which assure a protective skin protection effect, do so on a chemical-physical basis without interfering with the physiology of the skin. Such preparations must fulfill the following requirements: They should be impermeable and insoluble with respect to most of the exogenic harmful substances; they should have a good skin compatability; they should be easily applied to the skin surface and also easily removed therefrom; they should not interfere with the feel of the hands, so as not to interfere with the workability of the hands and should also have a certain prolonged period of effectiveness. The disadvantage of known preparations of this type is that they are not able to fullfill all these requirements to the optimum degree required.
It is an objective in the conserving skin care to make the skin less allergic when coming into contact with skin damaging substances. The protecting substances are already contained in the washing substances. Their efects differ in accordance with different types of skin protection measures sought and, which take effect effect by adsorption at the skin surface, lubricating measures, acidifying measures and deswelling measures. Here too, the essential disadvantage of these skin protective measures consists in that they are not effective in the same manner against attack by the different environmental harmful substances.
In contrast thereto, skin treating compositions containing a 3-amino-tetrahydro-1,3-thiazine-2,4-dione of the general formula I ##STR1## wherein R.sup.1 and R.sup.2 each represent H, alkyl, hydroxyalkyl, carboxyalkyl, halogenalkyl, cyanoalkyl, alkoxyalkyl, cycloalkyl, alkenyl, alkinyl, arylalkyl, arylalkyl substituted in the aryl moiety, aryl, alkyl-, halogen-, nitro-, alkoxy-, aryloxy-, cyano substituted aryl, acyl, thiazolyl, thienyl, benzthiazolyl, 1,3,4-thiadiaxolyl, oxazolyl, benzoxazolyl, 1,3,5-oxadiazolyl, pyrazolyl, 1,2,4-triazolyl, benzimidazolyl, pyridinyl, pyrimidinyl, purinyl, pyridazinyl, triazinyl, benzotriazinyl, quinolyl, isoquinolyl, cinnolinyl, phthalazolyl, pteridinyl, quinoxalinyl, acridinyl, or R.sup.1 and R.sup.2 taken together stand for alkylidene arylidene and heterocyclic-methylidene, wherein heterocyclic represents furan thiophene, pyrrole, pyridine, isozazole, thiazole, imidazole, 1,2,3-triazole, pyrazole, indole, benzthiazole, quinoline isoquinoline, quinoxaline, carbazole pteridine or where R.sup.1 and R.sup.2 together with the nitrogen atom, to which they are bound, are part of a herocyclic ring and in this ring represent the segment--(CH.sub.2).sub.n --X--(CH.sub.2).sub.m --, wherein X=CH.sub.2, O, S, NR' (R'=alkyl, arylalkyl, aryl), n=0 to 3 and m=1 to 3, provided that n is O, only when X=CH.sub.2, substituted aryl, aryl, substituted aryl, 2-furyl or substituted 2-furyl, and or substituted aryl, preparation in view of its novel effectiveness.
Therefore, the subject matter of the described invention is skin treatment composit
REFERENCES:
patent: 4352929 (1982-10-01), Anderson et al.
W. Hanefeld et al., Archiv der Pharmazie, Weinheim, 315(2) pp. 103-119 (1982).
CRC Handbook of Chemistry and Physics pp. C-1, C-2, C-8 and C-33-40 (60th Edition) CRC Press, Boca Raton Florida C(81).
Hanefeld Wolfgang
Noser Friedrich
Rothlisberger Rudi
Ford John M.
Striker Michael J.
Wella Aktiengesellschaft
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