3-amino-propoxphenyl derivatives (l)

Details 3-amino-propoxphenyl derivatives (l) 3-amino-propoxphenyl derivatives (l)

2006-10-31

2006-10-31

Barts, Samuel (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

C514S652000, C514S529000, C514S534000, C514S651000

Reexamination Certificate

active

07129379

ABSTRACT:
Compounds of formula (Ia) as potent, β1-specific beta blockers with a short duration of action in the systemic circulation, wherein R is 3′,4′-dimethoxyphenyl, R1is hydrogen, and R2is selected from methyl, ethyl, propyl, isobutyl and isopropyl; or R is 3′,4′-dimethoxyphenyl, R1is selected from fluorine, chlorine and bromine, and R2is selected from methyl, ethyl, propyl, isopropyl, isobutyl and cyclopropylmethyl; of R is 4′-methoxyphenoxy, R1is selected from hydrogen, fluorine, chlorine and bromine, and R2is selected from methyl, ethyl, propyl, isopropyl, isobutyl and cyclopropylmethyl; or R is 3′,4′-dimethoxyphenyl, R1is cyano, and R2is cyclopropylmethyl; or R is 4′-methoxyphenoxy, R1is cyano, and R2is isobutyl; and physiologically acceptable hydrolysable derivatives thereof having the hydroxy group in the 2-position of the 3-aminopropoxy side chain in esterified form, in their racemic and optically active forms, and their pharmaceutically acceptable acid addition salts.

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