3-Amino-5-benzyl-1,2,4-oxadiazoles and anti-hypertensive composi

Details 3-Amino-5-benzyl-1,2,4-oxadiazoles and anti-hypertensive composi 3-Amino-5-benzyl-1,2,4-oxadiazoles and anti-hypertensive composi

1979-04-27

1980-12-30

Tovar, Jose

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Parasitic organism or component thereof or substance...

548133, C07D27106, A61K 3141

Patent

active

042423520

ABSTRACT:
1,2,4-Oxadiazole derivatives of the formula ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 =H, halogen or alkyl, or two of them represent the --CH.dbd.CH--CH.dbd.CH-- group required to form a fused benzene ring and R=an amino radical NR'R" or --N.dbd.CR'.sub.3 --NR'.sub.1 R'.sub.2, in which R', R", R'.sub.1 and R'.sub.2 =alkyl, hydroxyalkyl or N,N-dialkylaminoalkyl or NRR' or NR'.sub.1 R'.sub.2 =heterocyclic ring, and R' R" can also be H, dialkylaminoalkylcarbonyl and pyridinoalkyl, (at least two of R.sub.1 to R.sub.5 being other than H when R' and R"=H), are pharmaceutically useful as anti-hypertensive agents.

REFERENCES:
Duenow et al., "Zeitschrift fur Chemie", No. 3, pp. 94 & 95, (1974).

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