3-Amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine derivatives

Details 3-Amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine derivatives 3-Amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine derivatives

1984-08-03

1985-10-22

Bond, Robert T.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

2602393B, 2602393T, A61K 3155, C07D51304

Patent

active

045489327

ABSTRACT:
Novel 3-amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine derivatives of the formula ##STR1## [wherein R.sup.1 and R.sup.2 are independently hydrogen, halogen, trifluoromethyl, lower alkyl or lower alkoxy, or both jointly form tri- or tetramethylene; R.sup.3 is hydrogen, optionally substituted lower alkyl or optionally substituted aralkyl; R.sup.4 is hydrogen, optionally substituted alkyl, optionally substituted aralkyl or optionally substituted cycloalkylalkyl; Y is a carboxyl group which may be esterified or amidated; m is 1 or 2] and salts thereof.
These compounds and salts thereof exhibits inhibitory activity on angiotensin converting enzyme and so forth, and are of value as an agent for diagnosis, prevention and treatment of circulatory diseases (e.g. hypertension, cardiopathy, cerebral apoploxy).

REFERENCES:
patent: 3341519 (1967-09-01), Krapcho
patent: 4477464 (1984-10-01), Slade et al.
Chemical Abstracts, vol. 94, p. 657, (1981), Registry No. 94:156884t.
Central Patent Index, Basic Abstracts Journal, Section B: FARMDOC, 01015 E/01 B02 TANA 02.05.80, J56156-218, (Mar. 3, 1982).
Central Patent Index, Basic Abstracts Journal, Section B: FARMDOC, 82663 E/39 B02 NIPK 18.02.81, J57136-581, (Nov. 24, 1982).
Central Patent Index, Basic Abstracts Journal, Section B: FARMDOC, 01471J/47 B02 HAMA 13.04.81, J57169-474, (Jan. 26, 1983).

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