3-Amino-4-hydroxypyrrolidines

Details 3-Amino-4-hydroxypyrrolidines 3-Amino-4-hydroxypyrrolidines

1979-10-16

1981-03-03

Lee, Mary C.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Fungus, except allergen, or component thereof or substance...

26032633, 26032646, 26032647, 2603265R, 2603265B, 2603265C, 2603265L, C07D20714, A61K 3140

Patent

active

042541352

ABSTRACT:
Cis and trans 3-amino-4-hydroxypyrrolidines and derivatives thereof are disclosed having the formula: ##STR1## wherein R.sub.1 is hydrogen, loweralkyl or phenylcarbonyl; R.sub.2 is hydrogen, loweralkyl, lowercycloalkyl, phenyl or phenylloweralkyl; R.sub.3 is hydrogen, loweralkyl, phenylloweralkyl, phenylcarbonyl, diphenylmethyl, 5-yl-10,11-dihydro-5H-dibenzo[a,d]cycloheptene or naphthylcarbonyl; R.sub.4 is hydrogen, loweralkyl, phenylloweralkyl or lowercycloalkyl; phenyl is optionally substituted and acid addition salts thereof. The compounds have antidepressant activity and methods and pharmaceutical compositions for use thereof are disclosed.

REFERENCES:
patent: 3691198 (1972-09-01), Brown et al.
Beereboom et al., J. Org. Chem., vol. 30, pp. 2334-2342 (1965).

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