3-amino-3-carbamoyloxyalkylacrylic acid intermediates to dihydro

Details 3-amino-3-carbamoyloxyalkylacrylic acid intermediates to dihydro 3-amino-3-carbamoyloxyalkylacrylic acid intermediates to dihydro

1986-05-16

1988-04-19

Jiles, Henry R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

540544, 540575, 544121, 544128, 544130, 544131, 544139, 544140, 544141, 544143, 544154, 544165, 544168, 544357, 544360, 544363, 544370, 544371, 544372, 544373, 544400, 546153, 546157, 546190, 546193, 546194, 546200, 546201, 546206, 546208, 546210, 546233, 546234, 546247, 546261, 546272, 546273, 546278, 546279, 546281, 546291, 546309, 548300, 548356, 548455, 548465, 548482, 548491, 548518, 548568, 560 32, 560 33, 560115, C07D21114, C07D21375, C07D20908, C07C125073

Patent

active

047391065

ABSTRACT:
A process for preparing a 2-carbamoyloxyalkyl-1,4-dihydropyridine derivative represented by the general formula: ##STR1## which comprises: (a) reacting a 3-amino-3-carbamoyloxyalkylacrylic acid derivative represented by the general formula: ##STR2## with a benzylidene compound represented by the general formula: ##STR3## (b) reacting the 3-amino-3-carbamoyloxyalkylacrylic acid derivative of the general formula II with an aldehyde compound represented by the general formula: ##STR4## and a .beta.-keto-ester compound represented by the general formula:

REFERENCES:
patent: 4188395 (1980-02-01), Bossert et al.
patent: 4404378 (1983-09-01), Miyano et al.
patent: 4430333 (1984-02-01), Campbell et al.
Chemical Abstracts, vol. 99, 1983, 88063a, 1,4-Dihydropyridines and Their Use as Hypotensives.
Chemical Abstracts, vol. 93, 1980, 168138v, Dihydropyridines with Substituted Ester Groups.
Chemical Abstracts, vol. 80, 1974, 133275s, Antihypertensive and Coronary Dilating 2-amino-4,5-dihydro-3,5-pyridinedicarboxylates.
European Search Report of Jun. 11, 1985, No. 83 107 707.8.
Ullmans Encyklopadie der Technischen Chemie, (1954), by Dr. Gunter Wachtershauser.
Chemical Abstracts, vol. 99, 1983, 38373f, 1,4-Dyhydropyridine Derivative.

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