Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1994-06-17
1998-02-03
Ivy, C. Warren
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
5142225, 5142372, 5142378, 514252, 514255, 514256, 514326, 514369, 514425, 544 8, 544129, 544162, 544309, 544310, 546208, 546209, 548184, 548185, 548544, A61K 31445, C07D40112
Patent
active
057144990
ABSTRACT:
The present invention discloses peptide aldehydes which are potent and specific inhibitors of thrombin, their pharmaceutically acceptable salts, pharmaceutically acceptable compositions thereof, and methods of using them as therapeutic agents for disease states in mammals characterized by abnormal thrombosis.
REFERENCES:
Skiles, J.W. et al, Biorg. Med. Chem. Lett. 1993, 3(4), pp. 773-778.
R. Freidinger, et al., "Protected Lactam-Bridged Dipeptides for Use as Conformational Constraints in Peptides," J. Org. Chem., 47:104-109, 1982.
H. Vieweg, et al., "Synthese von N-alpha-(arylsulphonylglycyl)-3-amidinophenulalaninest ern als aktive and relativ spezfische Inhibtoren von Faktor Xa," Pharmazie, vol. 42, No. 4, Apr. 1987, Berlin DD p. 268.
G. Wagner, et al., "Synthese von N-alpha-(Tosyl-beta-alanyl)-und N-alpha-(Tosyl-espsilon-aminocapronyl) amidinophenylalanylamiden als stark wirksame thrombininhititoren,"Pharmazie, vol. 39, No. 5, May 1984, Berlin DD pp. 315-317.
D. Carini, et al., "Nonpeptide Angiotensin II Receptor Antagoists:The Discovery of a Series of V-(Biphenylylmethyl) imidazoles as Potent, Orally Active Antihypertensives," J. Med. Chem., vol. 34, No. 8, pp. 2525-2547, 1991.
Levy Odile E.
Nutt Ruth F.
Ripka William C.
Semple Joseph E.
Corvas International Inc.
Dahlen Garth M.
Ivy C. Warren
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