Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Tripeptides – e.g. – tripeptide thyroliberin – etc.
Patent
1995-06-07
1997-12-30
Johnson, Jerry D.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
Tripeptides, e.g., tripeptide thyroliberin , etc.
540463, 540487, 540524, 540527, 546 24, 546192, 546243, 548413, 548517, 548547, 514 18, 514 19, 514 20, A61K 3806, A61K 3800, C07D22502, C07F 906
Patent
active
057032084
ABSTRACT:
The present invention discloses peptide aldehydes which are potent and specific inhibitors of thrombin, their pharmaceutically acceptable salts, pharmaceutically acceptable compositions thereof, and methods of using them as therapeutic agents for disease states in mammals characterized by abnormal thrombosis.
Ardecky Robert John
Brunck Terence Kevin
Lim-Wilby Marguerita S. L.
Nutt Ruth Foelsche
Ripka William Charles
Corvas International Inc.
Johnson Jerry D.
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