3-amino-2-hydroxypropyl of pyrimidin-4-one useful as antihyperte

Details 3-amino-2-hydroxypropyl of pyrimidin-4-one useful as antihyperte 3-amino-2-hydroxypropyl of pyrimidin-4-one useful as antihyperte

1984-03-02

1986-07-01

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

544295, 544296, 544333, 544334, 544335, 544357, 544405, 546276, 548518, 549 59, 549 68, 549472, 549480, C07D23902, C07D40300, A61K 31505

Patent

active

045981493

ABSTRACT:
The novel compounds of this invention and their pharmaceutically acceptable salts exhibit cardioselective .beta.-adrenergic blocking activity, with a direct relaxing effect on the .beta..sub.2 -adrenergic receptors and are useful as antihypertensive, cardioprotective, antiarrhythmic and, antianginal agents.

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patent: 4115575 (1978-09-01), Froi et al.
patent: 4195090 (1980-03-01), Froi et al.
patent: 4410530 (1983-10-01), Frei et al.
Alfred Burger, Medicinal Chem. 2nd edition, 1960, p. 42.
Antonio et al., Chem. Abst. 88:31869m.
Frei et al., Chem. Abst. 86:121372g.
Frei et al., Chem. Abst. 81:135967p.

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