3-Amino-2-hydroxyalkanoic acids and their prodrugs

Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acid esters

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C560S155000, C562S433000, C562S553000

Reexamination Certificate

active

07030262

ABSTRACT:
Compounds having the formulaare useful for treating conditions which arise from or are exacerbated by angiogenesis. Also disclosed are pharmaceutical compositions comprising the compounds, methods of treatment using the compounds, methods of inhibiting angiogenesis, and methods of treating cancer.

REFERENCES:
patent: 6242494 (2001-06-01), Craig et al.
patent: 2002/0002152 (2002-01-01), Craig et al.
patent: 99/57098 (1999-11-01), None
Kaji et al, Bull. Chem. Soc Jpn, 49, pp 3181-3184 (1976); Rich et al, Journal of Org. Chem., 45, pp 2288-2290 (1980).
Matsuda et al, Bull. Chem. Soc. Jpn. 655 (2) pp 360-365 (1992); Peet et al, J. Med. Chemistry, 33(1) pp 394-407 (1990).
Ojima et al, Tetrahedron Letters, 33 (39) pp5537-5700 (1992).
Peet et al, J. Med. Chemistry, 33(1) pp 394-407 (1990).
Craig, et al., Chemical Abstract. Database accession No. 135:3311987 CA, XP002262659.
Database Crossfire Beilstein, Database accession No. brn 5486092, XP002262661; Tetrahedron Letters 33(39):5737-5740 (1992).
Database Crossfire Beilstein. Database accession No. brn 3650004, XP002262660; Tetrahedron Letters 34(47):7557-7560 (1993).
Database Crossfire Beilstein. Database accession No. brn 4803192, XP02262662; Bull. Chem. Soc. Jpn. 65(2):360-365 (1992).
Database Crossfire Beilstein. Database accession No. brn 1721653, XP002262663; Chem Zentralbl 77(11):765 (1906).
Database Crossfire Beilstein. Database accession No. brn 2430446, XP002262664; Bull. Chem. Soc. Jpn. 49:3181-3184 (1976).
Database Crossfire Beilstein. Database accession No. brn 2968669, XP002262665: J. Med. Chem. 33(12):394-407 (1990).
Database Crossfire Beilstein. Database accession No. brn 2970752, XP002262666; J. Med. Chem. 33(1):694-407 (1990).
Database Crossfire Beilstein. Database accession No. brn 3536828, XP002262667; J. Med. Chem. 33(1):694-407 (1990).
Database Crossfire Beilstein. Database accession No. brn 3609285, XP002262668; Tetrahedron 48(10):1853-1868 (1992).
Database Crossfire Beilstein. Database accession No. brn 4230470, XP002262669; J. Org. Chem. 45(12):2288-2290 (1980).
Database Crossfire Beilstein. Database accession No. brn 4231872, XP002262670; Bioorg. Med. Chem. Lett. 10(20):2305-2310 (2000).
Database Crossfire Beilstein. Database accession No. brn 5486837, XP00226267;Tetrahedron Lett. 33(39):5737-5740 (1992).
Database Crossfire Beilstein. Database accession No. brn 5740104, XP002262672; J. Org. Chem. 50(1):91-97 (1985).
Database Crossfire Beilstein. Database accession No. brn 5862099, XP002262673; Tetrahedron Lett. 34(3):504-504 (1993).
Database Crossfire Beilstein. Database accession No. brn 5906442, XP002262674; Tetrahedron Lett. 34(8):1247-1250 (1993).
Database Crossfire Beilstein. Database accession No. brn 6592217, XP002262675; Tetrahedron Lett. 34(47):7557-7560 (1993).
Database Crossfire Beilstein. Database accession No. brn 6844111, XP002262676; Tetrahedron: Asymmetry 5(2):203-206 (1994).
Database Crossfire Beilstein. Database accession No. brn 7566877, XP002262667; J. Antibiot. 49(9):890-899 (1996).
Griffith et al., “Methionine aminopeptidase (type 2) is the common target for angiogenesis inhibitors AGM-1470 and ovalicin”, Chemistry and Biology 4(6):461-471 (1997).
Sin et al., “The anti-angiogenic agent fumagillin covalently binds and inhibits the methionine aminopeptidase, MetAP-2”, Proc. Natl. Acad. Sci. USA 94:6099-6103 (1997).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

3-Amino-2-hydroxyalkanoic acids and their prodrugs does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 3-Amino-2-hydroxyalkanoic acids and their prodrugs, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 3-Amino-2-hydroxyalkanoic acids and their prodrugs will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3580309

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.