3'-Amino-2' halo-anthracycline antibiotics

Details 3'-Amino-2' halo-anthracycline antibiotics 3'-Amino-2' halo-anthracycline antibiotics

1983-04-22

1985-12-31

Brown, Johnnie R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536 64, 536122, A61K 3171, C07H 1524

Patent

active

045621772

ABSTRACT:
Compounds of the formula ##STR1## wherein R.sup.1 is a hydrogen atom or a hydroxyl group; R.sup.2 is a hydrogen atom or a hydroxyl or methoxyl group; X is a fluorine, chlorine, bromine or iodine atom; one of Y and Y' is a hydrogen atom and the other is a hydrogen atom or a hydroxyl or acyloxy group; R.sup.3 and R.sup.4 are each independently a hydrogen atom, an alkyl group, a halo- or phenyl-substituted alkyl group, an acyl group or a halo- or phenyl-substituted acyl group or R.sup.3 and R.sup.4 together form a polymethylene chain having 4 to 6 carbon atoms, are useful as anti-tumor agents, especially for treating leukemia; in particular these compounds exhibit high antileukemic activity against P388 murine leukemia.

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patent: 4201773 (1980-05-01), Horton et al.
patent: 4345070 (1980-08-01), Suarato et al.
Fuchs, Ernst-F et al., Carbohydrate Research, 57:C36-C39, (1977).
Cheung, Tak Ming et al., Carbohydrate Research, 58:139-151, (1977).
Horton, Derek et al., Carbohydrate Research, 77:C8-C11, (1977).

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