3-Amino-2-cyano-3-(5-amino-3-phenyl-isoxazole-4-yl)-acrylonitril

Details 3-Amino-2-cyano-3-(5-amino-3-phenyl-isoxazole-4-yl)-acrylonitril 3-Amino-2-cyano-3-(5-amino-3-phenyl-isoxazole-4-yl)-acrylonitril

1981-11-18

1983-06-07

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546115, C07D49804

Patent

active

043872310

ABSTRACT:
Process for the production of 4,6-diamino-5-cyano-3-aryl-isoxazole [5,4-b] pyridines having the formula: ##STR1## wherein (a) R.sup.1 and R.sup.2 are --H or (b) R.sup.1 is --Cl and R.sup.2 is --H, or (c) R.sup.1 is --CH.sub.3 and R.sup.2 is --H or (d) R.sup.1 is --NO.sub.2 and R.sup.2 is --H, or (e) R.sup.1 is --H and R.sup.2 is --NO.sub.2. 2-Amino-1-propane-1,1,3-tricarbonitrile having the formula: ##STR2## is reacted with a benzohydroxamino acid chloride having the formula: ##STR3## wherein R.sup.1 and R.sup.2 have the same meaning as above, in the presence of a strong base in at least a molar quantity.

REFERENCES:
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Chemical Abstracts, vol. 85, 21450s.
W. Janssen and T. Denzel, Arch. Pharmax., 308, (1972), pp. 471-479.
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Quilico et al., Gazz. chim. ital., 67, 1937, pp. 589 to 603.

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