3-amino-2,3-dihydro-1-benzoxepine compounds and pharmaceutical c

Details 3-amino-2,3-dihydro-1-benzoxepine compounds and pharmaceutical c 3-amino-2,3-dihydro-1-benzoxepine compounds and pharmaceutical c

1985-11-04

1987-06-09

Milestone, Norma S.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514239, 514254, 514320, 514422, 514222, 514256, 514450, 544147, 544 63, 544 96, 544 62, 544 55, 544 3, 544376, 544238, 544333, 546269, 548525, 549355, C07D41704, C07D41304, C07D40504, C07D31308, A61K 31335, A61K 3140, A61K 31535, A61K 31495

Patent

active

046720626

ABSTRACT:
3-amino-2,3-dihydro-1-benzoxepine compounds corresponding to the general Formula I ##STR1## wherein R.sub.1 and R.sub.2 may each be hydrogen, halogen, lower alkyl or lower alkoxy, or if one of R.sub.1 and R.sub.2 is hydrogen, the other may also be nitro or trifluoromethyl, R.sub.3 represents hydrogen or a lower alkyl group which optionally may be substituted by hydroxy, lower alnoxy, an optionally substituted phenyl group or an optionally substituted amino group, and R.sub.4 represents hydrogen or lower alkyl, or R.sub.3 and R.sub.4 together with the nitrogen atom form a 5 or 6 member heterocycle. The compounds exhibit pharmacological, especially antidepressive, activity.

REFERENCES:
patent: 4279904 (1981-07-01), Ohlendorf et al.

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