3-Amino(1H,3H)quinazoline-2,4-dione derivatives and their therap

Details 3-Amino(1H,3H)quinazoline-2,4-dione derivatives and their therap 3-Amino(1H,3H)quinazoline-2,4-dione derivatives and their therap

1980-03-11

1981-05-19

Sutto, Anton H.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

424251, 544116, 544285, 544 94, 544164, A61K 3147, C07D23980, C07D41304

Patent

active

042685117

ABSTRACT:
This invention relates to compounds having the formula: ##STR1## in which R.sub.1 and R.sub.2 are independently hydrogen, a C.sub.1-4 alkyl group or an aliphatic or aromatic acyl group, provided R.sub.1 and R.sub.2 are not simultaneously hydrogen, or, together with the nitrogen atom to which they are attached, R.sub.1 and R.sub.2 form a 5- or 6-membered ring which may carry another heteroatom; R.sub.3 is a C.sub.1-4 alkyl group; and R.sub.4 and R.sub.5 represent independently a hydrogen or halogen atom, a C.sub.1-4 alkyl group or a C.sub.1-4 alkoxy group; and the acid addition salts of the above compounds. Said new compounds have an anxiolytic and diuretic action, together with a spasmolytic action of non-.alpha.-adrenalytic nature on the unstriated muscle fibers.

REFERENCES:
patent: 3718648 (1973-02-01), Beyerle et al.
patent: 3819630 (1974-06-01), Parcell
patent: 3932409 (1976-01-01), Konzel et al.

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