3-Amino-17a-aza-D-homoandrostane compounds, and pharmaceutical c

Details 3-Amino-17a-aza-D-homoandrostane compounds, and pharmaceutical c 3-Amino-17a-aza-D-homoandrostane compounds, and pharmaceutical c

1978-08-17

1980-04-29

Rollins, Alton D.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

544361, 546 77, 424258, C07D40104, A61K 31495, C07D40110, A61K 3147

Patent

active

042006368

ABSTRACT:
The invention relates to new 3-amino-17a-aza-D-homo-5.alpha.-androstane derivatives of the general formula I ##STR1## wherein R.sub.1 represents a methylene or an >N--CH.sub.3 group, and n stands for 1 or 2, and the acid addition salts and the quaternary salts of the general formula ##STR2## thereof, wherein R.sub.2 stands for an alkyl or alkenyl group having from 1 to 4 carbon atoms, and A represents a halogen atom, provided that if R.sub.1 stands for an >N--CH.sub.3 group, R.sub.2 is attached to the nitrogen of that >N--CH.sub.3 group. The new compound possess a non-polarizing neuromuscular blocking activity and have a short activity period.

REFERENCES:
Gandiha, A. et al., J. Pharm. Pharmacol., 1974, vol. 26, pp. 871-877. _
Morrison, R. and R. Boyd, "Organic Chemistry," 3rd ed., Allyn and Bacon, Inc. Boston, 1976, p. 520. _
Muller, Eugen, "Methoden der Organischen Chemie", Houben-Wail-Bond X1/1-Stickstoffverbindungen II Amine, (1957), p. 243. _
Sidgwick, N. "The Organic Chemistry of Nitrogen", Clarendon Press, Oxford, (1966), p. 250. _

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