3-Amino-[1]-benzazepin-2-one-1-alkanoic acids

Details 3-Amino-[1]-benzazepin-2-one-1-alkanoic acids 3-Amino-[1]-benzazepin-2-one-1-alkanoic acids

1984-02-09

1986-03-11

Bond, Robert T.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

2602393B, 2602393T, A61K 3155, C07D22316

Patent

active

045755035

ABSTRACT:
Variously substituted 1-carboxymethyl-3-(carboxymethylamino)-2,3,4,5-tetrahydro-1H-[1]benzazepin -2-ones and functional derivatives are angiotensin converting enzyme inhibitors and are useful as antihypertensive agents. Synthesis of, compositions and methods of treatment utilizing such compounds are included.

REFERENCES:
patent: 4410520 (1983-10-01), Watthey
patent: 4473575 (1984-09-01), Watthey
Derwent Abstract, 85-081046/13 (1985) of South African Patent Document 8303903 (Oct. 1, 1984).
Watthey, et al., 186th ACS National Meeting, Aug. 28-Sep. 2, 1983, Abstract No. 93.
Chen et al., The Pharmacologist, vol. 25, No. 3; (1983) CGS 14824A and CGS 14831.
Miller et al., The Pharmacologist, vol. 25, No. 3 (1983) CGS 14824A.
Parsons et al., Biochemical and Biophysical Research Communications 117, pp. 108-113 (1983).

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