3-Amino-(1)-benzazepin-2-one-1-alkanoic acids

Details 3-Amino-(1)-benzazepin-2-one-1-alkanoic acids 3-Amino-(1)-benzazepin-2-one-1-alkanoic acids

1983-02-10

1984-09-25

Bond, Robert T.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

2602393B, 2602393T, 424244, 424267, 424274, C07D22316, A61K 3155

Patent

active

044735758

ABSTRACT:
Variously substituted 1-carboxymethyl-3-(carboxymethylamino)-2,3,4,5-tetrahydro-1H-[1]benzazepin -2-ones and functional derivatives are angiotensin converting enzyme inhibitors and are useful as antihypertensive agents. Synthesis of, compositions and methods of treatment utilizing such compounds are included.

REFERENCES:
patent: 3748321 (1973-07-01), Krapcho
patent: 4409146 (1983-10-01), Thersett et al.
patent: 4410520 (1983-10-01), Watthey
patent: 4415496 (1983-11-01), Harris et al.
Stewart "Australian J. of Chemistry", vol. 33, (1980), pp. 633-640.
Friedinger et al., "J. Org. Chem.", vol. 47, (1962), pp. 104-109.
Paquette et al., "J. Org. Chem.", vol. 34, (1969), pp. 2879-2880.
Smith, "J. Medicinal Chem.", vol. 24, (1981), pp. 104-109.
Patchett et al., "Nature", vol. 288, pp. 280-283, (1980).
PTO Official Gazette, Abstract of U.S. Pat. No. 4,409,146, issued Nov. 13, 1983.
PTO Official Gazette, Abstract of U.S. Pat. No. 4,409,149, issued Oct. 11, 1983.

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