3-amidoindolyl derivatives and pharmaceutical compositions there

Details 3-amidoindolyl derivatives and pharmaceutical compositions there 3-amidoindolyl derivatives and pharmaceutical compositions there

1991-11-12

1993-02-23

Lee, Mary C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548483, A61K 31405, C07D20914

Patent

active

051890542

ABSTRACT:
The present invention is directed to a new class of 3-amido and 3-sulfamido-indolyl NMDA antagonists and their use in the treatment of a number of disease states.

REFERENCES:
patent: 4960786 (1990-10-01), Salituro
Monge et al., J. Heterocyclic Chemistry, 24, pp. 437-439 (1987).
Bailey, et al., J. C. S. Perkin I, pp. 1602-1606, (1973).
J. T. Greenamyre, "The Role of Glutamate in Neurotransmission and in Neurologic Disease," Arch Neurol, vol. 43, pp. 1058-1063 (1986).
J. W. Olney, "Excitatory Amino Acids and Neuropsychiatric Disorders," Biol Psychiatry 26, pp. 505.525 (1989).
M. B. Robinson et al., "Glutamate and Related Acidic Excitatory Neurotransmitters: from Basic Science to Clinical Application," FASEB J. 1:446-455 (1987).
R. Dingledine et al., "Excitatory Amino Acid Receptors in Epilepsy," TiPS vol. 11, pp. 334-338 (1990).

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