Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2007-11-06
2007-11-06
Shameem, Golam M. M. (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C548S240000, C548S241000, C514S378000, C514S380000
Reexamination Certificate
active
10493702
ABSTRACT:
The present invention relates to 3-amido-1,2-benzoisoxazole derivatives and their salts represented by formula 1, processes for preparation and usees thereof. More particularly, it relates to a method for improving its bioavailability introducing amino acid residue to the amine group of a 3-amido-1,2-benzoisoxazole. The compounds according to the present invention are used as an antagonist against Leukotriene-B-4 receptor, an inhibitor or therapeutics of osteoroposis, thus inhibiting osteolysis and stimulating osteogensis.
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patent: 2-237956 (1990-09-01), None
patent: WO98/33779 (1998-08-01), None
Franchi-Miller, C. et al., “The 5-lipoxygenase Inhibitor BWA4C Impairs Osteoclastic Resorption in a Synchronized Model of Bone Remodeling”. Bone, vol. 17, No. 2, Aug. 1995, pp. 185-191.
Kuwabara, Kenji, et al., “Effects of the second-generation leukotriene B4receptor antagonist, LY293111Na, on leukocyte infiltration and collagen-induced arthritis in mice”. European Journal of Pharmacology, vol. 402, 2000, pp. 275-285.
Suh, Hongsuk, et al., “3-Amino-1,2-benzisoxazoles: A New Family of Potent Inhibitors of LTB, Binding to the Human Neutrophils”. Bioorganic & Medical Chemistry Letters, vol. 7, No. 4, 1997, pp. 389-392.
Ahn Seok-Hoon
Cho Sun-Ki
Chung Yong-Ho
Jin Sang-Mi
Jin Young-Goo
Dongwha Pharm. Ind. Co., Ltd.
Harkins Tanya E.
Nath Gary M.
Shameem Golam M. M.
The Nath Law Group
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