3.alpha.-Arylhydroisoindoles

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Fungus – except allergen – or component thereof or substance...

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260326R, 2603261, 26032644, 2603463, 260465D, 260465F, 260473R, 260515R, 2605705R, 2605706, A61K 3140, C07D20944

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active

040427072

ABSTRACT:
Certain 3.alpha.-arylhydroisoindoles are useful as analgesics and/or narcotic antagonists. Exemplary is N-cyclopropylmethyl-3.alpha.-(m-methoxyphenyl)-5,6-dimethyl-2,3,3.alpha.,4 ,7,7.alpha.-trans-hexahydroisoindole.

REFERENCES:
patent: 3031459 (1962-04-01), Huebner
patent: 4001248 (1977-01-01), Zimmerman et al.
Gschwend et al., "J. Org. Chem.," vol. 41, pp. 104-110, (1976).
Armarego et al., "J. Chem. Soc.," vol. 19(c), pp. 3222-3229, (1971).
Kugita, "Chem. Abstracts," vol. 51, pp. 1992d-1993f, (1957).

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