3-Alkylxanthines, composition and methods for the treatment of c

Details 3-Alkylxanthines, composition and methods for the treatment of c 3-Alkylxanthines, composition and methods for the treatment of c

1984-07-25

1987-02-17

Rizzo, Nicholas S.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

544267, 544273, C07D47308, A61K 3152

Patent

active

046440011

ABSTRACT:
Compounds having activity against chronic obstructive airway disease or cardiac disease, characterized by the formula ##STR1## wherein R.sup.1 is n-propyl, n-butyl, isobutyl, n-pentyl, 2-methylbutyl, 3-methylbutyl, 2,2-dimethylpropyl, cyclopropyl, cyclobutyl, cyclopentyl or cyclohexylmethyl, and R.sup.2 is hydrogen or methyl, provided that R.sup.2 is methyl when R.sup.1 is n-propyl, n-butyl or isobutyl, or a physiologically acceptable salt thereof.

REFERENCES:
patent: 2517410 (1950-08-01), Papesch
patent: 4089959 (1978-05-01), Diamond
patent: 4233303 (1980-11-01), Bergstrand et al.
patent: 4546182 (1985-10-01), Kjellin et al.
patent: 4548818 (1985-10-01), Kjellin et al.
Chemical Abstract, Fifth Dec Index, p. 13540's (1962).
CA 8, 1974, 152277f.
J. Pharm. Exptl. Therap., 69, 45-51 (1940).
Ann. Chem. BD. 691, 142-158 (1966).
Bull. of the Johns Hopkins Hospital (Balt.), 89, pp. 1-8 (1951).
CA 74, 40820b.
CA 87, 98027h.

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