3-Alkoxyisoquinolines for hypotensive and vasodilating effects

Details 3-Alkoxyisoquinolines for hypotensive and vasodilating effects 3-Alkoxyisoquinolines for hypotensive and vasodilating effects

1976-12-22

1978-02-21

Rosen, Sam

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

A61K 3147

Patent

active

040753441

ABSTRACT:
New 2-substituted-3(2H)-isoquinolones and 2-substituted-3-alkoxyisoquinolines are disclosed. They are orally active hypotensives and peripheral vasodilators with an extended duration of action. Representative embodiments of this invention are 6,7-dimethoxy-2-methyl-1-veratryl-3(2H)-isoquinolone hydrochloride, 2-allyl-6,7-dimethoxy-2-veratryl-3(2H)-isoquinolone hydrochloride, 2-cyclopropyl-6,7-dimethoxy-1-3(2H)-isoquinolone hydrochloride, 2-amino-6,7-dimethoxy-1-veratryl-3(2H)-isoquinolone hydrochloride and 3-ethoxy-6,7-dimethoxy-1-veratrylisoquinoline.

REFERENCES:
patent: 2683713 (1954-07-01), Shephard
patent: 2728769 (1955-12-01), Shephard
Evans et al., J. Chem. Soc. (B) (1967), pp. 590-595.
Henderson, J. Amer. Pharm. Assoc., vol. 40 (1951), pp. 207-210.
Uff et al., Chem. Abst., vol. 70 (1969), p. 87533t.

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